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The product code for this leaflet is: PL04425/0374

 

Lasix Injection 20mg/2ml

Company Details

SANOFI


1 Onslow StreetGuildfordSurreyGU1 4YS
Telephone:
Fax:
Medical Information Direct Line:
Medical Information e-mail:uk-medicalinformation@sanofi.com
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PACKAGE LEAFLET: INFORMATION FOR THE USER

Lasix® 20mg/2 ml

Solution for Injection

Furosemide

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Phone 01483 505515 for help

Read all of this leaflet carefully before you start using this medicine

  • Keep this leaflet. You may need to read it again
  • If you have any further questions, ask your doctor or pharmacist
  • This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours
  • If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist

In this leaflet:

1. What Lasix Injection is and what it is used for
2. Before you are given Lasix Injection
3. How Lasix Injection is given
4. Possible side effects
5. How to store Lasix Injection
6. Further information

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1. What Lasix Injection is and what it is used for

What Lasix Injection is

The name of your medicine is Lasix 20mg/2ml Solution for Injection (called Lasix Injection throughout this leaflet). Lasix Injection contains a medicine called furosemide. Lasix Injection belongs to a group of medicines called diuretics (water tablets).

What Lasix Injection is used for

Lasix Injection can be used to help you lose extra water in your body very quickly. It is given when you cannot take a tablet or when you have a lot of extra water in your body.

Lasix Injection is often used when you have too much water around your heart, lungs, liver or kidneys.

How Lasix Injection works

Lasix Injection works by helping you to pass more water (urine) than you usually do. If the extra water in your body is not removed, it can put extra strain on the heart, blood vessels, lungs, kidneys or liver.

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2. Before you are given Lasix Injection

Do not have this medicine and tell your doctor if:

  • You are allergic (hypersensitive) to furosemide or any of the other ingredients of Lasix Injection (listed in Section 6 below)
    Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
  • You are allergic to sulphonamides such as sulfadiazine or co-trimoxazole
  • You have been told by a doctor that you have kidney failure. In some types of kidney failure, it is still okay to have this medicine. Your doctor will be able to decide
  • You have severe liver problems
  • Your doctor has told you that you have a low blood volume or are dehydrated
  • You are not passing any water (urine)
  • You have too little potassium or sodium in your blood (shown in blood tests)
  • You are breast-feeding (see “Pregnancy and breast-feeding” section below)

Do not use Lasix Injection if any of the above apply to you. If you are not sure, talk to your doctor or nurse before being given Lasix Injection.

Take special care with Lasix Injection

Check with your doctor or nurse before you have this medicine if:

  • You have difficulty in passing water (urine)
  • You are 65 years of age or older
  • You are an elderly patient with dementia and are also taking risperidone
  • You have liver or kidney problems
  • You have diabetes
  • You have low blood pressure or feel dizzy when you stand up
  • You have prostate problems
  • You have gout
  • You feel dizzy or dehydrated. This can happen if you have lost a lot of water through being sick, having diarrhoea or passing water very often. It can also happen if you are having trouble drinking or eating
  • You are going to have a glucose test
  • If the person having the medicine is a premature infant. This is due to the possible formation of kidney stones

If you are not sure if any of the above apply to you, talk to your doctor or nurse before being given Lasix Injection.

Taking other medicines

Please tell your doctor or nurse if you are taking or have recently taken any other medicines.

This includes medicines you buy without a prescription, including herbal medicines. This is because Lasix Injection can affect the way some other medicines work.

Also, some medicines can affect the way Lasix Injection works.

In particular, tell your doctor if you are taking any of the following:

The following medicines can affect the way Lasix Injection works and increase the chance of you getting side effects:

  • Medicines such as ramipril, enalapril, perindopril (called ‘ACE inhibitors’) or losartan, candesartan, irbesartan (called ‘angiotensin II receptor antagonists’). Your doctor may need to change the dose of your tablets or ask you to stop taking them
  • Medicines for high blood pressure or heart problems. Your doctor may need to change the dose of your medicine
  • Medicines used as a general anaesthetic for relaxing your muscles during surgery
  • Medicines for diabetes. These may not work as well when you are using Lasix Injection
  • Theophylline – used for wheezing or difficulty in breathing
  • Phenytoin – used for epilepsy. This can lower the effect of Lasix Injection

The following medicines can increase the chance of side effects when taken with Lasix Injection:

  • Lithium – used for mental illnesses. To help stop side effects your doctor may need to change the dose of your lithium and check the amount of lithium in your blood
  • Cisplatin – used for some cancers
  • Digoxin – used for heart problems. Your doctor may need to change the dose of your medicine
  • Non-steroidal anti-inflammatory drugs (NSAIDs) – used for pain and inflammation such as aspirin, ibuprofen, ketoprofen or indometacin
  • Carbamazepine – used for epilepsy
  • Aminoglutethimide – used for breast cancer
  • Ciclosporin – used to stop the rejection of organs after a transplant
  • Methotrexate – used for cancers of the skin, joint or bowel diseases
  • Carbenoxolone – used for ulcers of the food-pipe (gullet)
  • Reboxetine – used for depression
  • Amphotericin – used for fungal infections if used for a long time
  • Corticosteroids – used for inflammation (such as prednisolone)
  • Liquorice – often used in cough medicines if taken in large amounts
  • Probenecid (used with another HIV medicine)
  • Medicines for infection such as gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin or high doses of cephalosporins
  • Medicines used as injections before X-ray examinations
  • Medicines used for constipation (laxatives) if used for a long time such as bisacodyl or senna
  • Medicines for asthma when given in high doses such as salbutamol, terbutaline sulphate, salmeterol, formoterol or bambuterol
  • Other water tablets (diuretics) such as bendroflumethiazide. Your doctor may need to change the dose of your medicine

Pregnancy and breast-feeding

Do not have Lasix Injection if you are pregnant. Talk to your doctor before having this medicine if you are pregnant, might become pregnant, or think you might be pregnant.

Do not breast-feed if you are being given Lasix Injection. This is because small amounts may pass into the mother’s milk. Talk to your doctor before having this medicine if you are breast-feeding or planning to breast-feed.

Ask your doctor or nurse for advice before taking any medicine if you are pregnant or breast-feeding.

Driving and using machines

You may feel dizzy or unwell after having Lasix Injection. If this happens, do not drive or use any tools or machines.

Important information about some of the ingredients of Lasix Injection

This injection contains:

  • Sodium. There is 7.4mg of sodium in 2ml of injection. This should be taken into consideration by patients on a controlled sodium diet.
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3. How Lasix Injection is given

Lasix Injection is normally given by a doctor or nurse. This is because it needs to be given as an injection into a vein or into a muscle.

How much Lasix Injection is given

If you are not sure why you are being given Lasix Injection or have any questions about how much Lasix Injection is being given to you, speak to your doctor or nurse. The usual doses are:

Adults and the elderly

The initial dose is 20mg to 50mg. This will then be gradually increased up to a maximum dose of 1500mg per day. If you are elderly you may be given a lower dose.

Children

The usual dose for children ranges from 0.5 to 1.5mg/kg body weight daily up to a maximum total daily dose of 20mg.

If you have more Lasix Injection than you should

It is unlikely that your doctor or nurse will give you too much medicine. Your doctor and nurse will monitor your progress, and check the medicine you are given. Always ask if you are not sure why you are getting a dose of medicine.

Having too much Lasix Injection may make you feel confused, unable to focus, show a lack emotion or interest in anything. You may also have dizziness, lightheadedness, fainting (due to low blood pressure), uneven heartbeat, muscle weakness or cramps and blood clots (signs include pain and swelling at the part of body that is affected). You may also have problems with your kidneys or blood.

If you miss a dose of Lasix Injection

Your doctor or nurse will have instructions on when to give you this medicine. It is unlikely that you will not be given the medicine as it has been prescribed. However, if you do think you have missed a dose, tell your doctor or nurse.

If you stop having Lasix Injection

Keep having Lasix Injection until your doctor tells you to stop.

Blood tests

Your doctor may carry out blood tests to check that the levels of some salts in the blood are at the correct levels.

If you have any further questions on the use of this product, ask your doctor or nurse.

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4. Possible side effects

Like all medicines, Lasix injection can cause side effects, although not everybody gets them.

Tell your doctor or nurse straight away if you notice any of the following serious side effects – you may need urgent medical treatment

  • If you have an allergic reaction. The signs may include inflammation of the kidney (nephritis), swollen ankles or high blood pressure, skin rashes, change in skin colour, severe blistering of the skin, being more sensitive to the sun than usual, high temperature (fever), and itching
  • Severe allergic reactions. The signs may include shock such as difficulty in breathing, cold clammy skin, pale skin colour and racing heart beat
  • Severe stomach or back pain. These could be signs of ‘pancreatitis’
  • Bruising more easily, getting more infections, feeling weak or tired more than usual. Lasix Injection can affect the number of blood cells, causing serious blood problems
  • Increased thirst, headache, feeling dizzy or light-headed, fainting, confusion, muscle or joint pains or weakness, cramps or spasms, stomach upsets or uneven heartbeats. These could be signs of dehydration or changes in your normal body chemicals. Severe dehydration can lead to blood clots or ‘gout’
  • You notice yellowing of your skin or eyes and your urine becomes darker in colour. These could be signs of a liver problem. In patients who already have liver problems, a more serious liver problem known as liver encephalopathy may occur. Symptoms include forgetfulness, fits, mood changes and coma
  • Blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever. This could be a condition called Stevens-Johnson syndrome. In a more severe form of the condition called Toxic Epidermal Necrolysis, layers of the skin may peel off to leave large areas of raw exposed skin all over the body

Tell your doctor as soon as possible if you have any of the following side effects:

  • Problems hearing or ringing in the ears (tinnitus). This especially affects people who already have problems with their kidneys
  • Tingling or feeling numb on the skin
  • Small changes in your mood such as feeling agitated or anxious
  • Headaches, feeling dizzy or light-headed when standing up quickly. Also loss of concentration, slower reactions, feeling sleepy or weak, problems with your sight, dry mouth. This could be due to low blood pressure

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet

  • Feeling sick (nausea) or a general feeling of being unwell, diarrhoea and being sick (vomiting) and constipation
  • People with bladder and prostate problems may notice pain when passing water. This is due to an increase in the amount of water passed
  • If you have diabetes you may be less able to control the levels of glucose in your blood
  • Passing more water (urine) than you usually do. This normally happens 1 or 2 hours after taking this medicine
  • Pain at the site of injection. This occurs when the medicine is injected into the muscle

Blood tests

Lasix Injection can change the levels of liver enzymes or body fats known as cholesterol and triglycerides.

If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

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5. How to store Lasix Injection

  • This medicine will be kept by your doctor or pharmacist in a safe place where children cannot see or reach it
  • The expiry date is stated on the carton and on the ampoules after EXP. The expiry date refers to the last day of that month
  • Store in the original package in order to protect from light

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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6. Further Information

What Lasix Injection contains

The active ingredient in this medicine is furosemide 20mg. This is the new name for frusemide 20mg. The ingredient itself has not changed

  • Each 2ml of Lasix Injection contains 20mg furosemide
  • The other ingredients are sodium hydroxide, sodium chloride and water for injection

What Lasix Injection looks like and contents of the pack

Lasix Injection is a clear, almost colourless solution.

Your injection is available in packs containing 5x 2ml amber glass ampoules.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

Sanofi-aventis
One Onslow Street
Guildford
Surrey
GU1 4YS
UK
Tel:01483 505515
Fax: 01483 535432
Email: uk-medicalinformation@sanofi-aventis.com

Manufacturer

Sanofi-Aventis Deutschland GmbH
Bruningstrasse 50
D-65926 Frankfurt am Main
Germany

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or nurse.

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This leaflet was last revised in 04/2011.

© Sanofi-aventis, 1973 – 2011

507075


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