Take special care with this medicine
Check with your doctor or pharmacist before taking your medicine if:
- You have ever had epilepsy, convulsions or fits.
- You have ever had problems with your liver or kidneys.
You have ever been told that you have a rare disease of the blood pigment called ‘porphyria’ or anyone in your family has it. This is because Avloclor may cause severe symptoms of porphyria, particularly if you drink alcohol.
- You have a scaly condition of the skin called psoriasis.
You have a muscle problem called ‘myasthenia gravis’. Avloclor can increase the symptoms of this condition. It can also reduce the effect of medicines used to treat this condition (neostigmine and pyridostigmine).
You have a blood problem called ‘glucose-6-phosphate dehydrogenase deficiency’. Avloclor may damage blood cells in people with this blood condition.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Avloclor.
If you go into hospital, tell the medical staff that you are taking Avloclor.
If you live in a country where malaria occurs, you may already be slightly immune to the disease. You must ask a doctor or pharmacist for advice before you take anti-malarial medicines.
Taking other medicines
Please tell your doctor or pharmacist if you are taking, or have recently taken, any other medicines. This includes medicines that you buy without a prescription and herbal medicines.
Tell your doctor or pharmacist if you are taking any of the following medicines. This is because Avloclor may affect the amount of these medicines in your blood.
- Praziquantel (used to treat infections of the bowel and bladder caused by parasites).
- Ciclosporin (mainly used by transplant patients but also used to treat rheumatoid arthritis and psoriasis).
- Anti-convulsant medicines (used to prevent convulsions or fits).
- Digoxin (used to treat heart problems).
Also tell your doctor or pharmacist if you are taking any of the following medicines:
Other medicines used to prevent malaria, such as mefloquine. There is a risk of convulsions or fits when these medicines are taken at the same time as Avloclor.
Cimetidine (used to treat stomach problems). This medicine affects how Avloclor is broken down by your body and may affect the amount of Avloclor in your blood.
- Medicines like kaolin (used for diarrhoea) which are called ‘adsorbents’.
Antacid medicines (aluminium, calcium and magnesium salts that are used to treat heartburn or indigestion).
Adsorbents and antacid medicines may reduce the amount of Avloclor absorbed from your gut. This may mean that the full dose of Avloclor is not absorbed into your body and it will not work properly. Therefore, you should take these medicines at least four hours before or after taking your Avloclor dose.
Some medicines (for example, ciprofloxacin, cimetidine, omeprazole, pyrimethamine) may increase the amount of Avloclor in your body and this can cause side effects. It is important that you do not take any additional medicines (either prescribed or non-prescribed) before speaking to your doctor.
If you need a vaccination against rabies, make sure you have it before you start your anti-malarial medicine. If you have your rabies injection at the same time as taking your anti-malarial medicine, your rabies vaccine might not work so well.